4 papers
DNA handles bias force-dependent looping times
Wout Laeremans, Jef Hooyberghs, Wouter G. Ellenbroek
DNA loop formation is a key mechanism in gene regulation, and looping kinetics are sensitive to mechanical tension acting on the DNA. In both single-molecule experiments and biolog…
Synthetic design of force-responsive hydrogels with ring-forming catch bonds
Wout Laeremans, Wouter G. Ellenbroek
Catch bonds are interactions whose lifetimes increase under mechanical load, a counterintuitive behaviour that underlies diverse biological processes. Translating this mechanism to…
Theoretical Models for Tension-Dependent DNA Looping Time
Wout Laeremans, Wouter G Ellenbroek
The influence of tension on DNA looping has been studied both experimentally and theoretically in the past. However, different theoretical models have yielded different predictions…
Polymer dynamics under tension: mean first passage time for looping
Wout Laeremans, Anne Floor den Ouden, Jef Hooyberghs +1
This study deals with polymer looping, an important process in many chemical and biological systems. We investigate basic questions on the looping dynamics of a polymer under tensi…