9 citations · 16 across the 10 of their papers we have counts for
11 papers
Dimensionality reduction for k-means clustering of large-scale influenza mutation datasets
Emilee Walden, Jiahui Chen, Guo-Wei Wei
Viral mutations pose significant threats to public health by increasing infectivity, strengthening vaccine resistance, and altering disease severity. To track these evolving patter…
Poisson-Boltzmann based machine learning (PBML) model for electrostatic analysis
Jiahui Chen, Yongjia Xu, Xin Yang +3
Electrostatics is of paramount importance to chemistry, physics, biology, and medicine. The Poisson-Boltzmann (PB) theory is a primary model for electrostatic analysis. However, it…
Integration of persistent Laplacian and pre-trained transformer for protein solubility changes upon mutation
JunJie Wee, Jiahui Chen, Kelin Xia +1
Protein mutations can significantly influence protein solubility, which results in altered protein functions and leads to various diseases. Despite of tremendous effort, machine le…
Mathematics-assisted directed evolution and protein engineering
Yuchi Qiu, Guo-Wei Wei
Directed evolution is a molecular biology technique that is transforming protein engineering by creating proteins with desirable properties and functions. However, it is experiment…
Persistent topological Laplacian analysis of SARS-CoV-2 variants
Xiaoqi Wei, Jiahui Chen, Guo-Wei Wei
Topological data analysis (TDA) is an emerging field in mathematics and data science. Its central technique, persistent homology, has had tremendous success in many science and eng…
Emerging dominant SARS-CoV-2 variants
Jiahui Chen, Rui Wang, Yuta Hozumi +4
Accurate and reliable forecasting of emerging dominant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants enables policymakers and vaccine makers to get prepared…
Topological AI forecasting of future dominating viral variants
Guo-Wei Wei
The understanding of the mechanisms of SARS-CoV-2 evolution and transmission is one of the greatest challenges of our time. By integrating artificial intelligence (AI), viral genom…
Persistent Laplacian projected Omicron BA.4 and BA.5 to become new dominating variants
Jiahui Chen, Yuchi Qiu, Rui Wang +1
Due to its high transmissibility, Omicron BA.1 ousted the Delta variant to become a dominating variant in late 2021 and was replaced by more transmissible Omicron BA.2 in March 202…
Mathematical artificial intelligence design of mutation-proof COVID-19 monoclonal antibodies
Jiahui Chen, Guo-Wei Wei
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have compromised existing vaccines and posed a grand challenge to coronavirus disease 2019 (COVID-19)…
Combinatorial and Hodge Laplacians: Similarity and Difference
Emily Ribando-Gros, Rui Wang, Jiahui Chen +2
As key subjects in spectral geometry and combinatorial graph theory respectively, the (continuous) Hodge Laplacian and the combinatorial Laplacian share similarities in revealing t…
Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2
Kaifu Gao, Rui Wang, Jiahui Chen +6
The deadly coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gone out of control globally. Despite much effort…