most citedComputing the Hazard Ratios Associated with Explanatory Variables Using Machine Learning Models of Survival Data

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cs.LG2021★ 38 cited

Computing the Hazard Ratios Associated with Explanatory Variables Using Machine Learning Models of Survival Data

Sameer Sundrani, James Lu

Purpose: The application of Cox Proportional Hazards (CoxPH) models to survival data and the derivation of Hazard Ratio (HR) is well established. While nonlinear, tree-based Machin…

cs.LG2020

Deep learning prediction of patient response time course from early data via neural-pharmacokinetic/pharmacodynamic modeling

James Lu, Brendan Bender, Jin Y. Jin +1

The longitudinal analysis of patient response time course following doses of therapeutics is currently performed using Pharmacokinetic/Pharmacodynamic (PK/PD) methodologies, which…