2 citations · 3 across the 4 of their papers we have counts for
4 papers
Nucleation and the transition state of the SH3 domain
Isaac A. Hubner, Katherine A. Edmonds, Eugene I. Shakhnovich
We present a verified computational model of the SH3 domain transition state (TS) ensemble. This model was built for three separate SH3 domains using experimental s in all-atom pro…
Of sequence and structure: Strategies of protein thermostability in evolutionary perspective
Igor N. Berezovsky, Eugene I. Shakhnovich
In this work we employ various methods of analysis (unfolding simulations and comparative analysis of structures and sequences of proteomes of thermophilic organisms) to show that…
Imperfect DNA Repair and the Error Catastrophe
Yisroel Brumer, Emmanuel Tannenbaum, Eugene I. Shakhnovich
In this Letter, we extend the semiconservative quasispecies equations to incorporate imperfect DNA lesion repair. We study the equilibrium behavior of this model in the limit of in…
An Exact Model of Fluctuations in Gene Expression
William W. Chen, Jeremy L. England, Eugene I. Shakhnovich
Fluctuations in the measured mRNA levels of unperturbed cells under fixed conditions have often been viewed as an impediment to the extraction of information from expression profil…