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stat.ME2023
Mediation Analysis with Mendelian Randomization and Efficient Multiple GWAS Integration
Rita Qiuran Lyu, Chong Wu, Xinwei Ma +1
Mediation analysis is a powerful tool for studying causal pathways between exposure, mediator, and outcome variables of interest. While classical mediation analysis using observati…
stat.ME2023
Winner's Curse Free Robust Mendelian Randomization with Summary Data
Zhongming Xie, Wanheng Zhang, Jingshen Wang +1
In the past decade, the increased availability of genome-wide association studies summary data has popularized Mendelian Randomization (MR) for conducting causal inference. MR anal…
stat.ME2023
Breaking the Winner's Curse in Mendelian Randomization: Rerandomized Inverse Variance Weighted Estimator
Xinwei Ma, Jingshen Wang, Chong Wu
Developments in genome-wide association studies and the increasing availability of summary genetic association data have made the application of two-sample Mendelian Randomization…