11 citations · 11 across the 5 of their papers we have counts for
6 papers
The Integration Host Factor is a pH-responsive protein that switches from DNA bending to DNA bridging in acidic biofilm-like conditions
Dinesh Parthasarathy, Saminathan Ramakrishnan, Georgia Tsang +9
The Integration Host Factor (IHF) is a nucleoid-associated protein critical for both DNA compaction and biofilm stability. While its role in DNA packaging within the cell is well u…
The transitional kinetics between open and closed Rep structures can be tuned by salt via two intermediate states
Jamieson A L Howard, Benjamin Ambrose, Mahmoud A S Abdelhamid +10
DNA helicases undergo conformational changes; however, their structural dynamics are poorly understood. Here, we study single molecules of superfamily 1A DNA helicase Rep, which un…
Correlating fluorescence microscopy, optical and magnetic tweezers to study single chiral biopolymers such as DNA
Jack W Shepherd, Sebastien Guilbaud, Zhaokun Zhou +7
Biopolymer topology is critical for determining interactions inside cell environments, exemplified by DNA where its response to mechanical perturbation is as important as biochemic…
Fluidification of entanglements by a DNA bending protein
Yair A. G. Fosado, Jamieson Howard, Simon Weir +3
In spite of the nanoscale and single-molecule insights into how nucleoid associated proteins (NAPs) interact with DNA, their role in modulating the mesoscale viscoelasticity of the…
Tetrameric UvrD helicase is located at the E. coli replisome due to frequent replication blocks
Adam J. M Wollman, Aisha H. Syeda, Andrew Leech +4
DNA replication in all organisms must overcome nucleoprotein blocks to complete genome duplication. Accessory replicative helicases in Escherichia coli, Rep and UvrD, help replicat…
Single-molecule FRET dynamics of molecular motors in an ABEL Trap
Maria Dienerowitz, Jamieson A. L. Howard, Steven D. Quinn +2
Single-molecule Förster resonance energy transfer (smFRET) of molecular motors provides transformative insights into their dynamics and conformational changes both at high temporal…