8 papers
Achieving detailed medial temporal lobe segmentation with upsampled isotropic training from implicit neural representation
Yue Li, Pulkit Khandelwal, Rohit Jena +8
Imaging biomarkers in magnetic resonance imaging (MRI) are important tools for diagnosing, tracking and treating Alzheimer's disease (AD). Neurofibrillary tau pathology in AD is cl…
Imaging Biomarkers for Neurodegenerative Diseases from Detailed Segmentation of Medial Temporal Lobe Subregions on in vivo Brain MRI Using Upsampling Strategy Guided by High-resolution ex vivo MRI
Yue Li, Pulkit Khandelwal, Long Xie +21
The medial temporal lobe (MTL) is a region impacted extensively and non-uniformly in early stages of Alzheimer's disease (AD). Regional MTL morphometric measures extracted from mag…
Regional Deep Atrophy: a Self-Supervised Learning Method to Automatically Identify Regions Associated With Alzheimer's Disease Progression From Longitudinal MRI
Mengjin Dong, Long Xie, Sandhitsu R. Das +5
Longitudinal assessment of brain atrophy, particularly in the hippocampus, is a well-studied biomarker for neurodegenerative diseases, such as Alzheimer's disease (AD). In clinical…
Improved Segmentation of Deep Sulci in Cortical Gray Matter Using a Deep Learning Framework Incorporating Laplace's Equation
Sadhana Ravikumar, Ranjit Ittyerah, Sydney Lim +29
When developing tools for automated cortical segmentation, the ability to produce topologically correct segmentations is important in order to compute geometrically valid morphomet…
Automated deep learning segmentation of high-resolution 7 T postmortem MRI for quantitative analysis of structure-pathology correlations in neurodegenerative diseases
Pulkit Khandelwal, Michael Tran Duong, Shokufeh Sadaghiani +34
Postmortem MRI allows brain anatomy to be examined at high resolution and to link pathology measures with morphometric measurements. However, automated segmentation methods for bra…
Gray Matter Segmentation in Ultra High Resolution 7 Tesla ex vivo T2w MRI of Human Brain Hemispheres
Pulkit Khandelwal, Shokufeh Sadaghiani, Michael Tran Duong +30
Ex vivo MRI of the brain provides remarkable advantages over in vivo MRI for visualizing and characterizing detailed neuroanatomy. However, automated cortical segmentation methods…
Deep Label Fusion: A 3D End-to-End Hybrid Multi-Atlas Segmentation and Deep Learning Pipeline
Long Xie, Laura E. M. Wisse, Jiancong Wang +6
Deep learning (DL) is the state-of-the-art methodology in various medical image segmentation tasks. However, it requires relatively large amounts of manually labeled training data,…
DeepAtrophy: Teaching a Neural Network to Differentiate Progressive Changes from Noise on Longitudinal MRI in Alzheimer's Disease
Mengjin Dong, Long Xie, Sandhitsu R. Das +5
Volume change measures derived from longitudinal MRI (e.g. hippocampal atrophy) are a well-studied biomarker of disease progression in Alzheimer's Disease (AD) and are used in clin…