activity
20192026
most citedSystematic Misestimation of Machine Learning Performance in Neuroimaging Studies of Depression

118 citations · 166 across the 10 of their papers we have counts for

collaborators

11 papers

q-bio.NC2026

Energy, Information, and the Limits of Neuropsychiatric Classification

Farbod Khodadadi, Mina Kheirkhah, Bita Shariatpanahi +15

Importance: The search for reliable neuroimaging biomarkers of mental disorders has remained elusive despite decades of research. Why clinically consequential disorders yield weak…

cs.CL2025

Roleplaying with Structure: Synthetic Therapist-Client Conversation Generation from Questionnaires

Doan Nam Long Vu, Rui Tan, Lena Moench +10

Large Language Models (LLMs) are promising tools for synthetic data generation in mental health. However, privacy policies and restrictions forced previous work to rely mainly on g…

eess.IV2024

deepmriprep: Voxel-based Morphometry (VBM) Preprocessing via Deep Neural Networks

Lukas Fisch, Nils R. Winter, Janik Goltermann +25

Voxel-based Morphometry (VBM) has emerged as a powerful approach in neuroimaging research, utilized in over 7,000 studies since the year 2000. Using Magnetic Resonance Imaging (MRI…

q-bio.QM2023★ 2 cited

Classification of Major Depressive Disorder Using Vertex-Wise Brain Sulcal Depth, Curvature, and Thickness with a Deep and a Shallow Learning Model

Roberto Goya-Maldonado, Tracy Erwin-Grabner, Ling-Li Zeng +84

Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if…

q-bio.NC2021★ 7 cited

More Alike than Different: Quantifying Deviations of Brain Structure and Function in Major Depressive Disorder across Neuroimaging Modalities

Nils R. Winter, Ramona Leenings, Jan Ernsting +28

Introduction: Identifying neurobiological differences between patients suffering from Major Depressive Disorder (MDD) and healthy individuals has been a mainstay of clinical neuros…

eess.SY2021★ 4 cited

A Network Control Theory Approach to Longitudinal Symptom Dynamics in Major Depressive Disorder

Tim Hahn, Hamidreza Jamalabadi, Daniel Emden +31

Background: The evolution of symptoms over time is at the heart of understanding and treating mental disorders. However, a principled, quantitative framework explaining symptom dyn…

q-bio.NC2021★ 1 cited

Genetic, Individual, and Familial Risk Correlates of Brain Network Controllability in Major Depressive Disorder

Tim Hahn, Nils R. Winter, Jan Ernsting +27

Background: A therapeutic intervention in psychiatry can be viewed as an attempt to influence the brain's large-scale, dynamic network state transitions underlying cognition and be…

cs.LG2021★ 1 cited

An Uncertainty-Aware, Shareable and Transparent Neural Network Architecture for Brain-Age Modeling

Tim Hahn, Jan Ernsting, Nils R. Winter +31

The deviation between chronological age and age predicted from neuroimaging data has been identified as a sensitive risk-marker of cross-disorder brain changes, growing into a corn…

eess.IV2021★ 9 cited

Predicting brain-age from raw T 1 -weighted Magnetic Resonance Imaging data using 3D Convolutional Neural Networks

Lukas Fisch, Jan Ernsting, Nils R. Winter +33

Age prediction based on Magnetic Resonance Imaging (MRI) data of the brain is a biomarker to quantify the progress of brain diseases and aging. Current approaches rely on preparing…

q-bio.NC2019★ 118 cited

Systematic Misestimation of Machine Learning Performance in Neuroimaging Studies of Depression

Claas Flint, Micah Cearns, Nils Opel +15

We currently observe a disconcerting phenomenon in machine learning studies in psychiatry: While we would expect larger samples to yield better results due to the availability of m…

q-bio.NC2019★ 24 cited

Biological sex classification with structural MRI data shows increased misclassification in transgender women

Claas Flint, Katharina Förster, Sophie A. Koser +16

Transgender individuals (TIs) show brain structural alterations that differ from their biological sex as well as their perceived gender. To substantiate evidence that the brain str…