17 citations · 31 across the 5 of their papers we have counts for
5 papers
Protein overabundance is driven by growth robustness
H. James Choi, Teresa W. Lo, Kevin J. Cutler +3
Protein expression levels optimize cell fitness: Too low an expression level of essential proteins will slow growth by compromising essential processes; whereas overexpression slow…
Noise robustness and metabolic load determine the principles of central dogma regulation
Teresa W. Lo, Han James Choi, Dean Huang +1
The processes of gene expression are inherently stochastic, even for essential genes required for growth. How does the cell maximize fitness in light of noise? To answer this quest…
The one-message-per-cell-cycle rule: A conserved minimum transcription level for essential genes
Teresa W. Lo, Han Kyou James Choi, Dean Huang +1
The inherent stochasticity of cellular processes leads to significant cell-to-cell variation in protein abundance. Although this noise has already been characterized and modeled, i…
The high-resolution in vivo measurement of replication fork velocity and pausing by lag-time analysis
Dean Huang, Anna E. Johnson, Brandon S. Sim +3
An important step towards understanding the mechanistic basis of the central dogma is the quantitative characterization of the dynamics of nucleic-acid-bound molecular motors in th…
Tesla's fluidic diode and the electronic-hydraulic analogy
Quynh M. Nguyen, Dean Huang, Evan Zauderer +3
Reasoning by analogy is powerful in physics for students and researchers alike, a case in point being electronics and hydraulics as analogous studies of electric currents and fluid…