3 papers
stat.AP2025
Joint TITE-CRM for Dual Agent Dose Finding Studies
Helen Barnett, Oliver Boix, Dimitris Kontos +1
Dual agent dose-finding trials study the effect of a combination of more than one agent, where the objective is to find the Maximum Tolerated Dose Combination (MTC), the combinatio…
stat.ME2024
How to Add Baskets to an Ongoing Basket Trial with Information Borrowing
Libby Daniells, Pavel Mozgunov, Helen Barnett +2
Basket trials test a single therapeutic treatment on several patient populations under one master protocol. A desirable adaptive design feature in these studies may be the incorpor…
stat.ME2024
Bayesian Model Averaging for Partial Ordering Continual Reassessment Methods
Luka Kovacevic, Thomas Jaki, Helen Barnett +1
Phase I clinical trials are essential to bringing novel therapies from chemical development to widespread use. Traditional approaches to dose-finding in Phase I trials, such as the…