119 citations · 339 across the 8 of their papers we have counts for
9 papers
A geometrical perspective on development
Archishman Raju, Eric D. Siggia
Cell fate decisions emerge as a consequence of a complex set of gene regulatory networks. Models of these networks are known to have more parameters than data can determine. Recent…
Geometry of Gene Regulatory Dynamics
David A. Rand, Archishman Raju, Meritxell Saez +2
Embryonic development leads to the reproducible and ordered appearance of complexity from egg to adult. The successive differentiation of different cell types, that elaborates this…
Inter-cellular Interactions and Patterns: Vertebrate Development and Embryonic Stem Cells
Eric D. Siggia
Development from egg to embryo to adult is a fascinating instance of biological self-organization for which genetics has supplied us with a parts list. It remains to find the princ…
Modeling mammalian gastrulation with embryonic stem cells
Eric D. Siggia, Aryeh Warmflash
Understanding cell fate patterning and morphogenesis in the mammalian embryo remains a formidable challenge. Recently, in vivo models based on embryonic stem cells (ESCs) have emer…
Extrinsic and intrinsic nucleosome positioning signals
Alexandre V. Morozov, Karissa Fortney, Daria A. Gaykalova +3
In eukaryotic genomes, nucleosomes function to compact DNA and to regulate access to it both by simple physical occlusion and by providing the substrate for numerous covalent epige…
Probabilistic Clustering of Sequences: Inferring new bacterial regulons by comparative genomics
Erik van Nimwegen, Mihaela Zavolan, Nikolaus Rajewsky +1
Genome wide comparisons between enteric bacteria yield large sets of conserved putative regulatory sites on a gene by gene basis that need to be clustered into regulons. Using the…