4 papers
A stochastic agent-based extension of the GSM2 model for particle therapy: cell-cycle dynamics, dose-rate dependence, and fractionation effects
Francesco G. Cordoni, Marco Battestini, Marta Missiaggia
Accurately linking microscopic energy deposition from ionizing radiation to emergent biological outcomes remains a central challenge in radiobiological modelling, particularly when…
Mechanistic driven TCP and NTCP modeling for particle therapy accounting for a broad range of physical irradiation parameters and tissue environmental conditions
Marco Battestini, Jules Morand, Giulio Bordieri +3
In conventional radiotherapy, the probability of controlling tumor growth is quantified using Tumor Control Probability (TCP) models. Instead, the probability of experiencing a sid…
A combined dose and microdosimetric modeling framework incorporating volume effects correlates with tissue sparing in proton minibeam radiotherapy
Giulio Bordieri, Marco Battestini, Gianluca Lattanzi +4
Proton minibeam (pMB) radiotherapy, delivers highly heterogeneous dose distributions alternating high-dose peaks and low-dose valleys. This aims to widen the therapeutic window by…
A multiscale radiation biophysical stochastic model describing the cell survival response at ultra-high dose rate
Marco Battestini, Marta Missiaggia, Sara Bolzoni +2
Ultra-high dose-rate (UHDR) radiotherapy, characterized by an extremely high radiation delivery rate, represents one of the most recent and promising frontier in radiotherapy. UHDR…