9 papers
A stochastic agent-based extension of the GSM2 model for particle therapy: cell-cycle dynamics, dose-rate dependence, and fractionation effects
Francesco G. Cordoni, Marco Battestini, Marta Missiaggia
Accurately linking microscopic energy deposition from ionizing radiation to emergent biological outcomes remains a central challenge in radiobiological modelling, particularly when…
Measurements of the micro-spill structure of medical cyclotron and synchrotron beams and its impact on pulse pileup
Matthias Knopf, Simon Waid, Stefan Gundacker +10
Detector characterization and instrumentation testing are often performed at cyclotron and synchrotron facilities, many of which were originally developed for medical applications…
Mechanistic driven TCP and NTCP modeling for particle therapy accounting for a broad range of physical irradiation parameters and tissue environmental conditions
Marco Battestini, Jules Morand, Giulio Bordieri +3
In conventional radiotherapy, the probability of controlling tumor growth is quantified using Tumor Control Probability (TCP) models. Instead, the probability of experiencing a sid…
One scale to rule them all: interpretable multi-scale Deep Learning for predicting cell survival after proton and carbon ion irradiation
Giulio Bordieri, Giorgio Cartechini, Anna Bianchi +4
The relationship between the physical characteristics of the radiation field and biological damage is central to both radiotherapy and radioprotection, yet the link between spatial…
A combined dose and microdosimetric modeling framework incorporating volume effects correlates with tissue sparing in proton minibeam radiotherapy
Giulio Bordieri, Marco Battestini, Gianluca Lattanzi +4
Proton minibeam (pMB) radiotherapy, delivers highly heterogeneous dose distributions alternating high-dose peaks and low-dose valleys. This aims to widen the therapeutic window by…
Machine Learning-based beam delivery time model for Mevion 250i with Hyperscan technology
Giorgio Cartechini, Francesco Giuseppe Cordoni, Mirko Unipan +1
Purpose: Accurate prediction of beam delivery time (BDT) is essential for operational efficiency, 4D dose calculations, and advanced proton therapy techniques. Despite its importan…