6 papers
SERS study of single-live-cell electrical permeabilization dynamics via plasmonic nanotubes
Yuge Liang, Peilin Xin, Enock Adjei Agyekum +7
There is a growing demand for minimally invasive methods to analyze intracellular processes and signaling activities in individual living cells, including the identification of tum…
AI-Driven SERS for Non-invasive and Label-Free Extracellular Vesicle Detection Across Cellular Origins in Tears and Sweat
Yang Li, Xiaoming Lyu, Ling Xia +5
Wearable sensing technology capable of point-of-care, continuous and non-invasive analysis of exosomes in biofluid such as tears and sweat is an essential part for future personali…
Label-free SERS Discrimination of Native Proline Hydroxylation at Single-molecule peptide by Deep Learning-assisted plasmonic nanopore
Yingqi Zhao, Kuo Zhan, Pei-Lin Xin +6
Post-translational modifications (PTMs) play essential roles in regulating protein structure, function, and cellular signalling. However, peptide level discrimination of hydroxylat…
Bridging Optical Sensing and Wearable Health Monitoring: A Functionalized Plasmonic Nanopillar for Non-Invasive Sweat Glucose Detection
Ling Liu, Kuo Zhan, Joni Kilpijärvi +8
Continuous glucose monitoring (CGM) is vital for diabetes care, but current systems rely on invasive implants or electrochemical sensors that often cause discomfort and skin irrita…
Label-free SERS Discrimination of Proline from Hydroxylated Proline at Single-molecule Level Assisted by a Deep Learning Model
Yingqi Zhao, Kuo Zhan, Pei-Lin Xin +4
Discriminating the low-abundance hydroxylated proline from hydroxylated proline is crucial for monitoring diseases and eval-uating therapeutic outcomes that require single-molecule…
Deep learning assisted SERS detection of prolines and hydroxylated prolines using nitrilotriacetic acid functionalized gold nanopillars
Yuan Zhang, Kuo Zhan, Peilin Xin +5
Proline (Pro) is one kind of proteinogenic amino acid and an important signaling molecule in the process of metabolism. Hydroxyproline (Hyp) is a product on Pro oxygen sensing post…