5 papers
SERS study of single-live-cell electrical permeabilization dynamics via plasmonic nanotubes
Yuge Liang, Peilin Xin, Enock Adjei Agyekum +7
There is a growing demand for minimally invasive methods to analyze intracellular processes and signaling activities in individual living cells, including the identification of tum…
Label-free SERS Discrimination of Native Proline Hydroxylation at Single-molecule peptide by Deep Learning-assisted plasmonic nanopore
Yingqi Zhao, Kuo Zhan, Pei-Lin Xin +6
Post-translational modifications (PTMs) play essential roles in regulating protein structure, function, and cellular signalling. However, peptide level discrimination of hydroxylat…
Resolving Single-Peptide Phosphorylation Dynamics in Plasmonic Nanopores using Physics-Informed Bi-Path Model
Mulusew W. Yaltaye, Yingqi Zhao, Kuo Zhan +2
Protein phosphorylation provides a dynamic readout of cellular signaling yet remains difficult to detect at low abundance and stoichiometry. Single-molecule surface-enhanced Raman…
Label-free SERS Discrimination of Proline from Hydroxylated Proline at Single-molecule Level Assisted by a Deep Learning Model
Yingqi Zhao, Kuo Zhan, Pei-Lin Xin +4
Discriminating the low-abundance hydroxylated proline from hydroxylated proline is crucial for monitoring diseases and eval-uating therapeutic outcomes that require single-molecule…
Deep learning assisted SERS detection of prolines and hydroxylated prolines using nitrilotriacetic acid functionalized gold nanopillars
Yuan Zhang, Kuo Zhan, Peilin Xin +5
Proline (Pro) is one kind of proteinogenic amino acid and an important signaling molecule in the process of metabolism. Hydroxyproline (Hyp) is a product on Pro oxygen sensing post…