7 papers
Sequential Multi-Step Nanoimprint Lithography Fabrication of Zero-Mode Waveguide Nanoaperture Arrays to Enhance Single Molecule Fluorescence Detection
Hamza Khelidj, Badre Kerzabi, Igor Ozerov +3
Zero-mode waveguides (ZMWs) enable single-molecule fluorescence detection at micromolar concentrations by confining light to nanoscale volumes, overcoming the diffraction limit of…
Single Nanoparticle Dynamics in Opto-Thermal Tweezers: Resolving the Temporal Resolution of Depletion Force Trapping
Jinchao Chen, Robert Talla Kontchou, Saurabh Rai +4
Optothermal tweezers enable the manipulation of a wide range of nano-objects through optically induced depletion forces. Despite significant advances, the temporal dynamics of opto…
Reconfigurable Magnetic Nanopore Platform for Selective Trapping
Nageswar Reddy Sanamreddy, Jeanne Maunier, Malavika Kayyil Veedu +5
Solid-state nanopores offer a powerful platform for nanoscale analysis of individual analytes, including biomolecules and functionalized nanoparticles, by confining them within a p…
Sel-assembled Rhodium Nanoantennas for Single-Protein UV SERS
Yanqiu Zou, Nicco Corduri, Francesco DAmico +11
Surface-enhanced Raman scattering (SERS) provides critical insights into analyte structure, dynamic processes, and intermolecular interactions at the single-molecule level. By expl…
DNA-Origami-Assembled Rhodium Nanoantennas for Deep-UV Label-Free Single-Protein Detection
Nicco Corduri, Malavika Kayyil Veedu, Yifan Yu +6
Nanoparticles of plasmonic metals have significantly to the development of spectroscopic techniques, enabling strong confinement of electromagnetic fields at the nanoscale and corr…
Breaking the Low Concentration Barrier of Single-Molecule Fluorescence Quantification to the Sub-Picomolar Range
Malavika Kayyil Veedu, Jérôme Wenger
Single-molecule fluorescence techniques provide exceptional sensitivity to probe biomolecular interactions. However, their application to accurately quantify analytes at the picomo…