2 papers
q-bio.QM2024
ANTIPASTI: interpretable prediction of antibody binding affinity exploiting Normal Modes and Deep Learning
Kevin Michalewicz, Mauricio Barahona, Barbara Bravi
The high binding affinity of antibodies towards their cognate targets is key to eliciting effective immune responses, as well as to the use of antibodies as research and therapeuti…
q-bio.QM2018
Direct Coupling Analysis of Epistasis in Allosteric Materials
Barbara Bravi, Riccardo Ravasio, Carolina Brito +1
In allosteric proteins, the binding of a ligand modifies function at a distant active site. Such allosteric pathways can be used as target for drug design, generating considerable…