3 papers
q-bio.SC2019
Modelling Protein Target-Search in Human Chromosomes
Markus Nyberg, Tobias Ambjörnsson, Per Stenberg +1
Several processes in the cell, such as gene regulation, start when key proteins recognise and bind to short DNA sequences. However, as these sequences can be hundreds of million ti…
physics.bio-ph2018
Genomic 3D-compartments emerge from unfolding mitotic chromosomes
Kumar Rajendra, Ludvig Lizana, Per Stenberg
The 3D organisation of the genome in interphase cells is not a randomly folded polymer. Rather, experiments show that chromosomes arrange into a network of 3D compartments that cor…
q-bio.GN2018
Mapping the spectrum of 3D communities in human chromosome conformation capture data
Sang Hoon Lee, Yeonghoon Kim, Sungmin Lee +4
Several experiments show that the three dimensional (3D) organization of chromosomes affects genetic processes such as transcription and gene regulation. To better understand this…