206 citations · 276 across the 10 of their papers we have counts for
10 papers
Scale invariance in early embryonic development
Miloš Nikolić, Victoria Antonetti, Feng Liu +6
The body plan of the fruit fly is determined by the expression of just a handful of genes. We show that the spatial patterns of expression for several of these genes scale precisel…
Finding the last bits of positional information
Lauren McGough, Helena Casademunt, Miloš Nikolić +3
In a developing embryo, information about the position of cells is encoded in the concentrations of "morphogen" molecules. In the fruit fly, the local concentrations of just a hand…
NucMM Dataset: 3D Neuronal Nuclei Instance Segmentation at Sub-Cubic Millimeter Scale
Zudi Lin, Donglai Wei, Mariela D. Petkova +12
Segmenting 3D cell nuclei from microscopy image volumes is critical for biological and clinical analysis, enabling the study of cellular expression patterns and cell lineages. Howe…
Trading bits in the readout from a genetic network
Marianne Bauer, Mariela D. Petkova, Thomas Gregor +2
In genetic networks, information of relevance to the organism is represented by the concentrations of transcription factor molecules. In order to extract this information the cell…
Precise spatial scaling in the early fly embryo
Victoria Antonetti, William Bialek, Thomas Gregor +3
The early fly embryo offers a relatively pure version of the problem of spatial scaling in biological pattern formation. Within three hours, a "blueprint" for the final segmented b…
Deciphering gene regulation from gene expression dynamics using deep neural network
Jingxiang Shen, Mariela D. Petkova, Yuhai Tu +2
Complex biological functions are carried out by the interaction of genes and proteins. Uncovering the gene regulation network behind a function is one of the central themes in biol…
Optimal decoding of information from a genetic network
Mariela D. Petkova, Gašper Tkačik, William Bialek +2
Gene expression levels carry information about signals that have functional significance for the organism. Using the gap gene network in the fruit fly embryo as an example, we show…
Positional information, positional error, and read-out precision in morphogenesis: a mathematical framework
Gašper Tkačik, Julien O Dubuis, Mariela D Petkova +1
The concept of positional information is central to our understanding of how cells in a multicellular structure determine their developmental fates. Nevertheless, positional inform…
Precision and reproducibility of macroscopic developmental patterns
Laurent Abouchar, Mariela D. Petkova, Cynthia R. Steinhardt +1
Developmental processes in multicellular organisms occur far from equilibrium, yet produce complex patterns with astonishing reproducibility. We measure the precision and reproduci…
Maternal origins of developmental reproducibility
Mariela D. Petkova, Feng Liu, Thomas Gregor
Cell fate decisions in multicellular organisms are precisely coordinated, leading to highly reproducible macroscopic outcomes of developmental processes. The origins of this reprod…