2 papers
stat.ME2020
Hi3+3: A Model-Assisted Dose-Finding Design Borrowing Historical Data
Yunshan Duan, Sue-Jane Wang, Yuan Ji
Background -- In phase I clinical trials, historical data may be available through multi-regional programs, reformulation of the same drug, or previous trials for a drug under the…
stat.ME2019
The i3+3 Design for Phase I Clinical Trials
Meizi Liu, Sue-Jane Wang, Yuan Ji
Purpose: The 3+3 design has been shown to be less likely to achieve the objectives of phase I dose-finding trials when compared with more advanced model-based designs. One major cr…