activity
20192025
most citedA computationally efficient physiologically comprehensive 3D-0D closed-loop model of the heart and circulation

91 citations · 227 across the 15 of their papers we have counts for

collaborators

17 papers

cs.CV2025★ 1 cited

Semantic-aware Random Convolution and Source Matching for Domain Generalization in Medical Image Segmentation

Franz Thaler, Martin Urschler, Mateusz Kozinski +3

We tackle the challenging problem of single-source domain generalization (DG) for medical image segmentation, where we train a network on one domain (e.g., CT) and directly apply i…

math.NA2025

AutoVARP -- a framework for automated reproducible inducibility testing in computational models of cardiac electrophysiology

Paolo Seghetti, Matthias Gsell, Anton Prassk +2

Simulations of Cardiac Electrophysiology are gaining momentum beyond basic mechanistic studies, as an approach for supporting clinical decision making. The potential for in silico…

math.NA2025

Computational Modeling of Selective Capture Mechanisms in Conduction System Pacing

Mohammadreza Kariman, Matthias A. F. Gsell, Edward J. Vigmond +3

CSP is gaining clinical significance owing to its ability to restore a physiological activation sequence in the ventricles. While His bundle pacing (HBP) producing the most physiol…

physics.med-ph2025

Non-Intrusive Parametrized-Background Data-Weak Reconstruction of Cardiac Displacement Fields from Sparse MRI-like Observations

Francesco C. Mantegazza, Federica Caforio, Christoph Augustin +3

Personalized cardiac diagnostics require accurate reconstruction of myocardial displacement fields from sparse clinical imaging data, yet current methods often demand intrusive acc…

math.NA2025★ 1 cited

An efficient end-to-end computational framework for the generation of ECG calibrated volumetric models of human atrial electrophysiology

Elena Zappon, Luca Azzolin, Matthias A. F. Gsell +12

Computational models of atrial electrophysiology (EP) are increasingly utilized for applications such as the development of advanced mapping systems, personalized clinical therapy…

q-bio.TO2025★ 3 cited

Integrating anatomy and electrophysiology in the healthy human heart: Insights from biventricular statistical shape analysis using universal coordinates

Lore Van Santvliet, Elena Zappon, Matthias A. F. Gsell +9

A cardiac digital twin is a virtual replica of a patient-specific heart, mimicking its anatomy and physiology. A crucial step of building a cardiac digital twin is anatomical twinn…

physics.med-ph2024★ 2 cited

Quantifying variabilities in cardiac digital twin models of the electrocardiogram

Elena Zappon, Matthias A. F. Gsell, Karli Gillette +1

Cardiac digital twins (CDTs) of human cardiac electrophysiology (EP) are digital replicas of patient hearts that match like-for-like clinical observations. The electrocardiogram (E…

physics.med-ph2024

pyCEPS: A cross-platform Electroanatomic Mapping Data to Computational Model Conversion Platform for the Calibration of Digital Twin Models of Cardiac Electrophysiology

Robert Arnold, Anton J. Prassl, Aurel Neic +7

Background and Objective: Data from electro-anatomical mapping (EAM) systems are playing an increasingly important role in computational modeling studies for the patient-specific c…

cs.CV2023

CaRe-CNN: Cascading Refinement CNN for Myocardial Infarct Segmentation with Microvascular Obstructions

Franz Thaler, Matthias A. F. Gsell, Gernot Plank +1

Late gadolinium enhanced (LGE) magnetic resonance (MR) imaging is widely established to assess the viability of myocardial tissue of patients after acute myocardial infarction (MI)…

physics.med-ph2022★ 25 cited

MedalCare-XL: 16,900 healthy and pathological 12 lead ECGs obtained through electrophysiological simulations

Karli Gillette, Matthias A. F. Gsell, Claudia Nagel +8

Mechanistic cardiac electrophysiology models allow for personalized simulations of the electrical activity in the heart and the ensuing electrocardiogram (ECG) on the body surface.…

physics.med-ph2022★ 4 cited

Comparison of propagation models and forward calculation methods on cellular, tissue and organ scale atrial electrophysiology

Claudia Nagel, Cristian Barrios Espinosa, Karli Gillette +5

Objective: The bidomain model and the finite element method are an established standard to mathematically describe cardiac electrophysiology, but are both suboptimal choices for fa…

math.NA2021

A coupling strategy for a 3D-1D model of the cardiovascular system to study the effects of pulse wave propagation on cardiac function

Federica Caforio, Christoph M. Augustin, Jordi Alastruey +2

The impact of increased stiffness and pulsatile load on the circulation and their influence on heart performance have been documented not only for cardiovascular events but also fo…

math.NA2021★ 26 cited

An accurate, robust, and efficient finite element framework for anisotropic, nearly and fully incompressible elasticity

Elias Karabelas, Matthias A. F. Gsell, Gundolf Haase +2

Fiber-reinforced soft biological tissues are typically modeled as hyperelastic, anisotropic, and nearly incompressible materials. To enforce incompressibility a multiplicative spli…

q-bio.TO2021★ 5 cited

Efficient identification of myocardial material parameters and the stress-free reference configuration for patient-specific human heart models

Laura Marx, Justyna A. Niestrawska, Matthias A. F. Gsell +3

Image-based computational models of the heart represent a powerful tool to shed new light on the mechanisms underlying physiological and pathological conditions in cardiac function…

q-bio.TO2020★ 91 cited

A computationally efficient physiologically comprehensive 3D-0D closed-loop model of the heart and circulation

Christoph M. Augustin, Matthias A. F. Gsell, Elias Karabelas +5

Computer models of cardiac electro-mechanics (EM) show promise as an effective means for quantitative analysis of clinical data and, potentially, for predicting therapeutic respons…

physics.med-ph2019★ 41 cited

Towards a Computational Framework for Modeling the Impact of Aortic Coarctations upon Left Ventricular Load

Elias Karabelas, Matthias A. F. Gsell, Christoph M. Augustin +6

Computational fluid dynamics (CFD) models of blood flow in the left ventricle (LV) and aorta are important tools for analyzing the mechanistic links between myocardial deformation…

physics.med-ph2019★ 28 cited

Assessment of wall stresses and mechanical heart power in the left ventricle: Finite element modeling versus Laplace analysis

Matthias A. F. Gsell, Christoph M. Augustin, Anton J. Prassl +6

Introduction: Stenotic aortic valve disease (AS) causes pressure overload of the left ventricle (LV) that may trigger adverse remodeling and precipitate progression towards heart f…