activity
20182026
most citedOptimal distributed control of an extended model of tumor growth with logarithmic potential

33 citations · 162 across the 26 of their papers we have counts for

collaborators

27 papers

math.OC2026

Optimal velocity control of a Brinkman-Cahn-Hilliard system with curvature effects

Pierluigi Colli, Gianni Gilardi, Andrea Signori +1

We address an optimal control problem governed by a system coupling a Brinkman-type momentum equation for the velocity field with a sixth-order Cahn-Hilliard equation for the phase…

math.AP2025

On Brinkman flows with curvature-induced phase separation in binary mixtures

Pierluigi Colli, Gianni Gilardi, Andrea Signori +1

The mathematical analysis of diffuse-interface models for multiphase flows has attracted significant attention due to their ability to capture complex interfacial dynamics, includi…

math.AP2025

Optimal Control of a Navier-Stokes-Cahn-Hilliard System for Membrane-fluid Interaction

Andrea Signori, Hao Wu

We consider an optimal control problem for a two-dimensional Navier-Stokes-Cahn-Hilliard system arising in the modeling of fluid-membrane interaction. The fluid dynamics is governe…

math.AP2025★ 1 cited

On a Cahn-Hilliard equation for the growth and division of chemically active droplets modeling protocells

Harald Garcke, Kei Fong Lam, Robert Nürnberg +1

The Cahn-Hilliard model with reaction terms can lead to situations in which no coarsening is taking place and, in contrast, growth and division of droplets occur which all do not g…

math.AP2024

Solvability and optimal control of a multi-species Cahn-Hilliard-Keller-Segel tumor growth model

Pierluigi Colli, Gianni Gilardi, Andrea Signori +1

This paper investigates an optimal control problem associated with a two-dimensional multi-species Cahn-Hilliard-Keller-Segel tumor growth model, which incorporates complex biologi…

math.AP2024

Curvature effects in pattern formation: well-posedness and optimal control of a sixth-order Cahn-Hilliard equation

Pierluigi Colli, Gianni Gilardi, Andrea Signori +1

This work investigates the well-posedness and optimal control of a sixth-order Cahn-Hilliard equation, a higher-order variant of the celebrated and well-established Cahn-Hilliard e…

math.AP2023

Well-posedness and optimal control for a viscous Cahn-Hilliard-Oono system with dynamic boundary conditions

Gianni Gilardi, Elisabetta Rocca, Andrea Signori

In this paper we consider a nonlinear system of PDEs coupling the viscous Cahn-Hilliard-Oono equation with dynamic boundary conditions enjoying a similar structure on the boundary.…

math.OC2023

Nutrient control for a viscous Cahn-Hilliard-Keller-Segel model

Gianni Gilardi, Andrea Signori, Jürgen Sprekels

In this paper, we address a distributed control problem for a system of partial differential equations describing the evolution of a tumor that takes the biological mechanism of ch…

math.OC2023

Regularity results and optimal velocity control of the convective nonlocal Cahn-Hilliard equation in 3D

Andrea Poiatti, Andrea Signori

In this contribution, we study an optimal control problem for the celebrated nonlocal Cahn-Hilliard equation endowed with the singular Flory-Huggins potential in the three-dimensio…

math.OC2023

Optimal temperature distribution for a nonisothermal Cahn-Hilliard system in two dimensions with source term and double obstacle potential

Pierluigi Colli, Gianni Gilardi, Andrea Signori +1

In this note, we study the optimal control of a nonisothermal phase field system of Cahn-Hilliard type that constitutes an extension of the classical Caginalp model for nonisotherm…

math.OC2023

Optimal temperature distribution for a nonisothermal Cahn-Hilliard system with source term

Pierluigi Colli, Gianni Gilardi, Andrea Signori +1

In this note, we study the optimal control of a nonisothermal phase field system of Cahn-Hilliard type that constitutes an extension of the classical Caginalp model for nonisotherm…

math.OC2022

Optimal control of a nonconserved phase field model of Caginalp type with thermal memory and double obstacle potential

Pierluigi Colli, Gianni Gilardi, Andrea Signori +1

In this paper, we investigate optimal control problems for a nonlinear state system which constitutes a version of the Caginalp phase field system modeling nonisothermal phase tran…

math.AP2022★ 1 cited

On a Cahn-Hilliard system with source term and thermal memory

Pierluigi Colli, Gianni Gilardi, Andrea Signori +1

A nonisothermal phase field system of Cahn-Hilliard type is introduced and analyzed mathematically. The system constitutes an extension of the classical Caginalp model for nonisoth…

math.AP2022★ 10 cited

Cahn-Hilliard-Brinkman model for tumor growth with possibly singular potentials

Pierluigi Colli, Gianni Gilardi, Andrea Signori +1

We analyze a phase field model for tumor growth consisting of a Cahn-Hilliard-Brinkman system, ruling the evolution of the tumor mass, coupled with an advection-reaction-diffusion…

math.OC2021

Analysis and optimal control theory for a phase field model of Caginalp type with thermal memory

Pierluigi Colli, Andrea Signori, Jürgen Sprekels

A nonlinear extension of the Caginalp phase field system is considered that takes thermal memory into account. The resulting model, which is a first-order approximation of a thermo…

math.AP2021★ 1 cited

Existence of weak solutions to multiphase Cahn-Hilliard-Darcy and Cahn-Hilliard-Brinkman models for stratified tumor growth with chemotaxis and general source terms

Patrik Knopf, Andrea Signori

We investigate a multiphase Cahn-Hilliard model for tumor growth with general source terms. The multiphase approach allows us to consider multiple cell types and multiple chemical…

math.OC2021

Optimal control problems with sparsity for phase field tumor growth models involving variational inequalities

Pierluigi Colli, Andrea Signori, Jürgen Sprekels

This paper treats a distributed optimal control problem for a tumor growth model of Cahn-Hilliard type including chemotaxis. The evolution of the tumor fraction is governed by a va…

math.OC2020

Second-order analysis of an optimal control problem in a phase field tumor growth model with singular potentials and chemotaxis

Pierluigi Colli, Andrea Signori, Jürgen Sprekels

This paper concerns a distributed optimal control problem for a tumor growth model of Cahn-Hilliard type including chemotaxis with possibly singular potentials, where the control a…

math.AP2020★ 2 cited

Strong well-posedness and inverse identification problem of a non-local phase field tumor model with degenerate mobilities

S. Frigeri, K. F. Lam, A. Signori

We extend previous weak well-posedness results obtained in Frigeri et al. (2017) concerning a non-local variant of a diffuse interface tumor model proposed by Hawkins-Daarud et al.…

math.AP2020★ 25 cited

On a class of non-local phase-field models for tumor growth with possibly singular potentials, chemotaxis, and active transport

Luca Scarpa, Andrea Signori

This paper provides a unified mathematical analysis of a family of non-local diffuse interface models for tumor growth describing evolutions driven by long-range interactions. Thes…

math.AP2019★ 19 cited

Optimal control of a phase field system modelling tumor growth with chemotaxis and singular potentials

Pierluigi Colli, Andrea Signori, Jürgen Sprekels

A distributed optimal control problem for an extended model of phase field type for tumor growth is addressed. In this model, the chemotaxis effects are also taken into account. Th…

math.AP2019★ 10 cited

Penalisation of Long Treatment Time and Optimal Control of a Tumour Growth Model of Cahn-Hilliard

Andrea Signori

A distributed optimal control problem for a diffuse interface model, which physical context is that of tumour growth dynamics, is addressed. The system we deal with comprises a Cah…

math.AP2019★ 8 cited

Boundary control problem and optimality conditions for the Cahn-Hilliard equation with dynamic boundary conditions

Pierluigi Colli, Andrea Signori

This paper is concerned with a boundary control problem for the Cahn--Hilliard equation coupled with dynamic boundary conditions. In order to handle the control problem, we restric…

math.AP2019★ 1 cited

Vanishing parameter for an optimal control problem modeling tumor growth

Andrea Signori

A distributed optimal control problem for a phase field system which physical context is that of tumor growth is discussed. The system we are going to take into account consists of…