40 citations · 76 across the 5 of their papers we have counts for
5 papers
OPENMENDEL: A Cooperative Programming Project for Statistical Genetics
Hua Zhou, Janet S. Sinsheimer, Christopher A. German +12
Statistical methods for genomewide association studies (GWAS) continue to improve. However, the increasing volume and variety of genetic and genomic data make computational speed a…
BioSimulator.jl: Stochastic simulation in Julia
Alfonso Landeros, Timothy Stutz, Kevin L. Keys +4
Biological systems with intertwined feedback loops pose a challenge to mathematical modeling efforts. Moreover, rare events, such as mutation and extinction, complicate system dyna…
Iterative Hard Thresholding for Model Selection in Genome-Wide Association Studies
Kevin L. Keys, Gary K. Chen, Kenneth Lange
A genome-wide association study (GWAS) correlates marker variation with trait variation in a sample of individuals. Each study subject is genotyped at a multitude of SNPs (single n…
Proximal Distance Algorithms: Theory and Examples
Kevin L. Keys, Hua Zhou, Kenneth Lange
Proximal distance algorithms combine the classical penalty method of constrained minimization with distance majorization. If is the loss function, and is th…
The proximal distance algorithm
Kenneth Lange, Kevin L. Keys
The MM principle is a device for creating optimization algorithms satisfying the ascent or descent property. The current survey emphasizes the role of the MM principle in nonlinear…