2 papers
q-bio.BM2020
Development of antibacterial compounds that block evolutionary pathways to resistance
Yanmin Zhang, Sourav Choudhury, Joao Rodrigues +1
Antibiotic resistance is a worldwide challenge. A potential approach to block resistance is to simultaneously inhibit WT and known escape variants of the target bacterial protein.…
q-bio.PE2019
Evolutionary dynamics determines adaptation to inactivation of an essential gene
João V. Rodrigues, Eugene Shakhnovich
Genetic inactivation of essential genes creates an evolutionary scenario distinct from escape from drug inhibition, but the mechanisms of microbe adaptations in such cases remain u…