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X-ray photon correlation spectroscopy of hydrated lysozyme at elevated pressures
Milla Åhlfeldt, Maddalena Bin, Anita Girelli +12
Pressure provides a powerful parameter to control the protein conformation state, which at sufficiently high values can lead to unfolding. Here, we investigate the effects of incre…
Depletion-Induced Interactions Modulate Nanoscale Protein Diffusion in Polymeric Crowder Solutions
Michelle Dargasz, Nimmi Das Anthuparambil, Sebastian Retzbach +26
Macromolecular crowding plays a crucial role in modulating protein dynamics in cellular and in vitro environments. Polymeric crowders such as dextran and Ficoll are known to induce…
Softness and Hydrodynamic Interactions Regulate Lipoprotein Transport in Crowded Yolk Environments
Nimmi Das Anthuparambil, Michelle Dargasz, Sonja Timmermann +27
Low-density lipoproteins (LDLs) serve as nutrient reservoirs in egg yolk for embryonic development and as promising drug carriers. Both roles critically depend on their mobility in…
Coherent X-rays reveal anomalous molecular diffusion and cage effects in crowded protein solutions
Anita Girelli, Maddalena Bin, Mariia Filianina +38
Understanding protein motion within the cell is crucial for predicting reaction rates and macromolecular transport in the cytoplasm. A key question is how crowded environments affe…