1 citations · 1 across the 6 of their papers we have counts for
6 papers
Branching-Time Signatures of Growth Regime in Tumor Birth-Death Models
Meng Wang, Zhangchi Weng, Jasmine Foo +1
Tumor evolution is shaped by cell division, cell death, competition, and constraints imposed by the local microenvironment. Because these dynamics are usually not observed directly…
Parameter Estimation in Recurrent Tumor Evolution with Finite Carrying Capacity
Kevin Leder, Zicheng Wang, Xuanming Zhang
In this work, we investigate the population dynamics of tumor cells under therapeutic pressure. Although drug treatment initially induces a reduction in tumor burden, treatment fai…
Parameter Estimation from Single Patient, Single Time-Point Sequencing Data of Recurrent Tumors
Kevin Leder, Ruping Sun, Zicheng Wang +1
In this study, we develop consistent estimators for key parameters that govern the dynamics of tumor cell populations when subjected to pharmacological treatments. While these trea…
Clonal Diversity at Cancer Recurrence
Kevin Leder, Zicheng Wang
Despite initial success, cancer therapies often fail due to the emergence of drug-resistant cells. In this study, we use a mathematical model to investigate how cancer evolves over…
Large Deviations of Cancer Recurrence Timing
Pranav Hanagal, Kevin Leder, Zicheng Wang
We study large deviation events in the timing of disease recurrence. In particular, we are interested in modeling cancer treatment failure due to mutation-induced drug resistance.…
Splitting Algorithms for Rare Events of Semimartingale Reflecting Brownian motions
Kevin Leder, Xin Liu, Zicheng Wang
We study rare event simulations of semimartingale reflecting Brownian motions (SRBMs) in an orthant. The rare event of interest is that a -dimensional positive recurrent SRBM en…