14 citations · 19 across the 7 of their papers we have counts for
7 papers
Nucleoid clustering drives stepwise expansion and segregation of replicating bacterial chromosomes
Giada Forte, Enzo Orlandini, Davide Marenduzzo
Bacterial chromosome replication occurs in the absence of a canonical spindle apparatus; yet it reliably produces organised and segregated genomes. While both passive and active me…
Supercoiling DNA with a free end
Daniela Moretti, Giuseppe Gonnella, Antonio Suma +3
In this work, we combine coarse-grained Brownian dynamics simulations and mean-field theory to study supercoiling dynamics, as well as the steady-state profiles of twist and writhe…
Modelling transcriptional silencing and its coupling to 3D genome organisation
Massimiliano Semeraro, Giuseppe Negro, Davide Marenduzzo +1
Timely up- or down-regulation of gene expression is crucial for cellular differentiation and function. While gene upregulation via transcriptional activators has been extensively i…
Bridging-Induced Phase Separation and Loop Extrusion Drive Noise in Chromatin Transcription
Michael Chiang, Cleis Battaglia, Giada Forte +3
Transcriptional noise, or heterogeneity, is important in cellular development and in disease. The molecular mechanisms driving it are, however, elusive and ill-understood. Here, we…
Modelling the 3D spatiotemporal organisation of chromatin replication
G. Forte, S. Buonomo, P. R. Cook +3
We propose a polymer model for the dynamics of chromatin replication in three dimensional space. Our simulations indicate that both immobile and tracking replisomes may self-assemb…
Cluster size determines internal structure of transcription factories in human cells
Massimiliano Semeraro, Giuseppe Negro, Giada Forte +4
Transcription is a fundamental cellular process, and the first step of gene expression. In human cells, it depends on the binding to chromatin of various proteins, including RNA po…
Plectoneme dynamics and statistics in braided polymers
Giada Forte, Michele Caraglio, Davide Marenduzzo +1
Braids composed of two interwoven polymer chains exhibit a buckling transition whose origin has been explained through the onset of plectonemic structures. Here we study, by a comb…