26 citations · 26 across the 2 of their papers we have counts for
2 papers
q-bio.BM2021
A novel hotspot of gelsolin instability and aggregation propensity triggers a new mechanism of amyloidosis
Michela Bollati, Luisa Diomede, Toni Giorgino +14
The multidomain protein gelsolin (GSN) is composed of six homologous modules, sequentially named G1 to G6. Single point substitutions in this protein are responsible for AGel amylo…
q-bio.BM2019★ 26 cited
Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant
Toni Giorgino, Davide Mattioni, Amal Hassan +8
AGel amyloidosis, formerly known as familial amyloidosis of the Finnish-type, is caused by pathological aggregation of proteolytic fragments of plasma gelsolin. So far, four mutati…