316 citations · 631 across the 15 of their papers we have counts for
15 papers
Femtosecond-to-millisecond holographic imaging of laser ablation dynamics
Shotaro Kawano, Keiichiro Toda, Miu Tamamitsu +3
Femtosecond laser ablation redistributes optically deposited energy across electronic, structural, mechanical, and thermal degrees of freedom over timescales from femtoseconds to m…
A unified framework for sensitivity comparison across stimulated Raman, stimulated Raman photothermal, and mid-infrared photothermal microscopy
Keiichiro Toda, Takuro Ideguchi
Label-free vibrational microscopy based on Raman scattering and mid-infrared (MIR) absorption has advanced biological imaging through the development of diverse high-sensitivity mo…
Mid-infrared photothermal imaging flow cytometry
Yusei Sugawara, Keiichiro Toda, Genki Ishigane +2
Imaging flow cytometry (IFC) enables high-throughput single-cell analysis but largely relies on fluorescence labeling to obtain molecular specificity. Label-free vibrational imagin…
Video-rate volumetric chemical imaging via mid-infrared photothermal optical diffraction tomography
Masato Fukushima, Keiichiro Toda, Yusei Sugawara +2
Label-free vibrational microscopy provides chemically specific access to cellular structure, yet quantitative volumetric chemical dynamics in living cells remain largely inaccessib…
Bidirectional quantitative scattering microscopy
Kohki Horie, Keiichiro Toda, Takuma Nakamura +1
Quantitative phase microscopy (QPM) and interferometric scattering (iSCAT) microscopy are powerful label-free imaging techniques and are widely used for biomedical applications. Ea…
Ludwig-Soret microscopy with vibrational photothermal effect
Keiichiro Toda, Takuro Ideguchi
Vibrational microscopy provides label-free, bond-selective chemical contrast by detecting molecular vibrations, making it invaluable for biomedical research. While conventional met…
Phase retrieval via Zernike phase contrast microscopy with an untrained neural network
Zinan Zhou, Keiichiro Toda, Rikimaru Kurata +3
Zernike's phase contrast microscopy (PCM) is among the most widely used techniques for observing phase objects, but it lacks quantitative nature, as it cannot directly provide phas…
Label-free mid-infrared photothermal microscopy revisits intracellular thermal dynamics: what do fluorescent nanothermometers measure?
Keiichiro Toda, Masaharu Takarada, Genki Ishigane +4
Fluorescent nanothermometry has revealed pronounced intracellular temperature heterogeneity, establishing the field of single-cell thermal biology. However, these observations have…
Mid-infrared wide-field nanoscopy
Miu Tamamitsu, Keiichiro Toda, Venkata Ramaiah Badarla +3
Mid-infrared (MIR) spectroscopy is widely recognized as a powerful, non-distractive method for chemical analysis. However, its utility is constrained by a micrometer-scale spatial…
Quantitative phase retrieval for Zernike phase-contrast microscopy
Rikimaru Kurata, Keiichiro Toda, Genki Ishigane +3
We present a single-image numerical phase retrieval method for Zernike phase-contrast microscopy (ZPM) that addresses halo and shade-off artifacts, as well as the weak phase condit…
Mid-infrared photothermal single-live-cell imaging beyond video rate
Genki Ishigane, Keiichiro Toda, Miu Tamamitsu +3
Advancement in mid-infrared (MIR) technology has led to promising biomedical applications of MIR spectroscopy, such as liquid biopsy or breath diagnosis. On the contrary, MIR micro…
Adaptive dynamic range shift (ADRIFT) quantitative phase imaging
Keiichiro Toda, Miu Tamamitsu, Takuro Ideguchi
Quantitative phase imaging (QPI) is often used for label-free single cell analysis with its high-contrast images of optical phase delay (OPD) map. Contrary to other imaging methods…
Label-free biochemical quantitative phase imaging with mid-infrared photothermal effect
Miu Tamamitsu, Keiichiro Toda, Hiroyuki Shimada +6
Label-free optical imaging is valuable in biology and medicine with its non-destructive property and reduced optical and chemical damages. Quantitative phase (QPI) and molecular vi…
Quantitative phase imaging with molecular vibrational sensitivity
Miu Tamamitsu, Keiichiro Toda, Ryoichi Horisaki +1
Quantitative phase imaging (QPI) quantifies the sample-specific optical-phase-delay enabling objective studies of optically-transparent specimens such as biological samples, but la…
Molecular contrast on phase-contrast microscope
Keiichiro Toda, Miu Tamamitsu, Ryoichi Horisaki +1
An optical microscope enables image-based findings and diagnosis on microscopic targets, which is indispensable in many scientific, industrial and medical settings. Majority of mic…