6 papers
Parsimonious computational inference protocol for Boolean networks: Application to osteogenesis
Jacques Demongeot, Alonso Espinoza Rojas, Eric Goles +3
Boolean networks are powerful mathematical tools for modeling the qualitative dynamics of genetic regulation. Yet inferred models often generate spurious attractors that lack biolo…
Solving decision problems by distributed consensus with one-dimensional, binary, radius- cellular automata over cyclic configurations
Eurico Ruivo, Pedro Paulo Balbi, Kévin Perrot +2
Probing the ability of automata networks to solve decision problems has received a continuous attention in the literature, and specially with the automata reaching the answer by di…
Boolean-network simplification and rule fitting to unravel chemotherapy resistance in non-small cell lung cancer
Alonso Espinoza, Eric Goles, Marco Montalva-Medel
Boolean networks are powerful frameworks for capturing the logic of gene-regulatory circuits, yet their combinatorial explosion hampers exhaustive analyses. Here, we present a syst…
Robustness of Boolean networks to update modes: an application to hereditary angioedema
Jacques Demongeot, Eric Goles, Houssem ben Khalfallah +2
Many familial diseases are caused by genetic accidents, which affect both the genome and its epigenetic environment, expressed as an interaction graph between the genes as that inv…
On the complexity of the generalized Q2R automaton
Eric Goles, Marco Montalva-Medel, Pedro Montealegre +1
We study the dynamic and complexity of the generalized Q2R automaton. We show the existence of non-polynomial cycles as well as its capability to simulate with the synchronous upda…
Phase space classification of an Ising Cellular Automaton: the Q2R model
Marco Montalva-Medel, Sergio Rica, Felipe Urbina
An exact characterization of the different dynamical behavior that exhibit the space phase of a reversible and conservative cellular automaton, the so called Q2R model, is shown in…