4 papers
A Joint Survival Modeling and Therapy Knowledge Graph Framework to Characterize Opioid Use Disorder Trajectories
Mengman Wei, Qian Peng
Motivation: Opioid use disorder (OUD) often arises after prescription opioid exposure and follows transitions among onset, remission, and relapse. Linked EHR-survey resources such…
DynoSys: A Dynamic Systems Framework for Multimodal Integration of Genetic, Environmental, and Neurobiological Signals
Mengman Wei, Qian Peng
Understanding the development of adolescent behavioral and mental health outcomes requires integrating genetic predisposition, environmental exposures, and neurobiological processe…
Time-Varying Environmental and Polygenic Predictors of Substance Use Initiation in Youth: A Survival and Causal Modeling Study in the ABCD Cohort
Mengman Wei, Qian Peng
Early substance use initiation is associated with later substance use disorders, but the relative contributions of environmental, behavioral, and genetic factors during adolescence…
Hillclimb-Causal Inference: A Data-Driven Approach to Identify Causal Pathways Among Parental Behaviors, Genetic Risk, and Externalizing Behaviors in Children
Mengman Wei, Qian Peng
Motivation: Externalizing behaviors in children, such as aggression, hyperactivity, and defiance, are influenced by complex interplays between genetic predispositions and environme…