2 papers
q-bio.BM2020
A native chemical chaperone in the human eye lens
Eugene Serebryany, Sourav Chowdhury, Nicki E. Watson +2
Cataract is one of the most prevalent protein aggregation disorders and still the biggest cause of vision loss worldwide. The human lens, in its core region, lacks turnover of any…
q-bio.BM2019
Conformational catalysis of cataract-associated aggregation by interacting intermediates in a human eye lens crystallin
Eugene Serebryany, Rostam Razban, Eugene I Shakhnovich
Most known proteins in nature consist of multiple domains. Interactions between domains may lead to unexpected folding and misfolding phenomena. This study of human γD-crystallin,…