71 citations · 147 across the 7 of their papers we have counts for
4 papers · 1 filter
ImmunoLingo: Linguistics-based formalization of the antibody language
Mai Ha Vu, Philippe A. Robert, Rahmad Akbar +4
Apparent parallels between natural language and biological sequence have led to a recent surge in the application of deep language models (LMs) to the analysis of antibody and othe…
Linguistically inspired roadmap for building biologically reliable protein language models
Mai Ha Vu, Rahmad Akbar, Philippe A. Robert +4
Deep neural-network-based language models (LMs) are increasingly applied to large-scale protein sequence data to predict protein function. However, being largely black-box models a…
Improving generalization of machine learning-identified biomarkers with causal modeling: an investigation into immune receptor diagnostics
Milena Pavlović, Ghadi S. Al Hajj, Chakravarthi Kanduri +5
Machine learning is increasingly used to discover diagnostic and prognostic biomarkers from high-dimensional molecular data. However, a variety of factors related to experimental d…
AntBO: Towards Real-World Automated Antibody Design with Combinatorial Bayesian Optimisation
Asif Khan, Alexander I. Cowen-Rivers, Antoine Grosnit +12
Antibodies are canonically Y-shaped multimeric proteins capable of highly specific molecular recognition. The CDRH3 region located at the tip of variable chains of an antibody domi…