17 citations · 48 across the 12 of their papers we have counts for
13 papers
Localization of Active Particles on Random Arrays of Parallel Filaments
Owen Santoso, Elena Koslover
Quenched disorder in the environment can fundamentally alter transport dynamics in both active and passive systems. We explore how disordered arrays of filaments govern the distrib…
Encounter Times of Intermittently Running Particles
Lizzy Teryoshin, Mario Hidalgo-Soria, Elena F. Koslover
Intracellular processes often rely on the timely encounter of mobile reaction partners, including intermittently motor-driven organelles. The underlying cytoskeletal network presen…
Diffusive Spreading Across Dynamic Mitochondrial Network Architectures
Keaton B. Holt, Camryn Zurita, Lizzy Teryoshin +2
In eukaryotic cells, mitochondria form networks that range from highly fused interconnected structures to fragmented populations of individual organelles that undergo transient int…
Many Will Enter, Few Will Win: Cost and Sensitivity of Exploratory Dynamics
Elena F Koslover, Milo M Lin, Rob Phillips
A variety of biomolecular systems rely on exploratory dynamics to reach target locations or states within a cell. Without a mechanism to remotely sense and move directly towards a…
Clustering and spatial distribution of mitochondria in dendritic trees
Mario Hidalgo-Soria, Elena F. Koslover
Neuronal dendrites form densely branched tree architectures through which mitochondria must be distributed to supply the cell's energetic needs. Dendritic mitochondria circulate th…
ER network heterogeneity guides diffusive transport and kinetics
Zubenelgenubi C. Scott, Katherine Koning, Molly Vanderwerp +3
The endoplasmic reticulum (ER) is a dynamic network of interconnected sheets and tubules that orchestrates the distribution of lipids, ions, and proteins throughout the cell. The i…
Diffusive Exit Rates Through Pores in Membrane-Enclosed Structures
Zitao Yang, Elena F. Koslover
The function of many membrane-enclosed intracellular structures relies on release of diffusing particles that exit through narrow pores or channels in the membrane. The rate of rel…
Unraveling Single-Particle Trajectories Confined in Tubular Networks
Yunhao Sun, Zexi Yu, Christopher J. Obara +3
The analysis of single particle trajectories plays an important role in elucidating dynamics within complex environments such as those found in living cells. However, the character…
Diffusive search and trajectories on spatial networks: a propagator approach
Zubenelgenubi C. Scott, Aidan I. Brown, Saurabh S. Mogre +2
Several organelles in eukaryotic cells, including mitochondria and the endoplasmic reticulum, form interconnected tubule networks extending throughout the cell. These tubular netwo…
Design principles for the glycoprotein quality control pathway
Aidan I Brown, Elena F Koslover
Newly-translated glycoproteins in the endoplasmic reticulum (ER) often undergo cycles of chaperone binding and release in order to assist in folding. Quality control is required to…
Impact of global structure on diffusive exploration of organelle networks
Aidan I Brown, Laura M Westrate, Elena F Koslover
We investigate diffusive search on planar networks, motivated by tubular organelle networks in cell biology that contain molecules searching for reaction partners and binding sites…
Thermal Fracture Kinetics of Heterogeneous Semiflexible Polymers
Alexander Lorenzo, Enrique M. De La Cruz, Elena F. Koslover
The fracture and severing of polymer chains plays a critical role in the failure of fibrous materials and the regulated turnover of intracellular filaments. Using continuum wormlik…
Multi-modal transport and dispersion of organelles in narrow tubular cells
Saurabh Mogre, Elena F. Koslover
Intracellular components explore the cytoplasm via active motor-driven transport in conjunction with passive diffusion. We model the motion of organelles in narrow tubular cells us…