5 papers
Stochastic multi-step cell size homeostasis model for cycling human cells
Sayeh Rezaee, Cesar Nieto, Abhyudai Singh
Measurements of cell size dynamics have established the adder principle as a robust mechanism of cell size homeostasis. In this framework, cells add a nearly constant amount of siz…
Intrinsic limits of timekeeping precision in gene regulatory cascades
Juan Sebastian Hernandez, Cesar Nieto, Juan Manuel Pedraza +1
Multiple cellular processes are triggered when the concentration of a regulatory protein reaches a critical threshold. Previous analyses have characterized timing statistics for si…
Dynamical Inference of Cell Size Regulation Parameters
Cesar Nieto, Sayeh Rezaee, Cesar Augusto Vargas-Garcia +1
Cells achieve size homeostasis by regulating their division timing based on their size, added size, and cell cycle time. Previous research under steady-state conditions demonstrate…
Information and fitness in two-state systems: self-replicating individuals in a fluctuating environment
Poulami Chatterjee, Cesar Nieto, Juan Manuel Pedraza +1
A population of individuals with the same genes can present heterogeneous traits (phenotypes). The prevalence of this heterogeneity can be explained as a bet-hedging strategy that…
Characterization of cell division control strategies through continuous rate models
Cesar Augusto Nieto-Acuna, Juan Carlos Arias-Castro, Carlos Arturo Sanchez-Isaza +2
Recent experiments have supported the Adder model for E. coli division control. This model posits that bacteria grow, on average, a fixed size before division. It also predicts dec…