244 citations · 508 across the 40 of their papers we have counts for
40 papers
TrialAtlas: Multi-Agent Research Organization for Clinical Trial Design and Optimization
Jiacheng Lin, Zifeng Wang, Zheng Chen +5
Nearly 90% of drugs entering clinical development ultimately fail, despite billions of dollars in investment. Pharmaceutical companies therefore rely on clinical development planni…
DeepEvidence: Empowering Biomedical Discovery with Deep Knowledge Graph Research
Zifeng Wang, Zheng Chen, Ziwei Yang +5
Biomedical knowledge graphs (KGs) encode vast, heterogeneous information spanning literature, genes, pathways, drugs, diseases, and clinical trials, but leveraging them collectivel…
Adaptation of Agentic AI: A Survey of Post-Training, Memory, and Skills
Pengcheng Jiang, Jiacheng Lin, Zhiyi Shi +31
Large language model (LLM) agents are moving beyond prompting alone. ChatGPT marked the rise of general-purpose LLM assistants, DeepSeek showed that on-policy reinforcement learnin…
BioDSA-1K: Benchmarking Data Science Agents for Biomedical Research
Zifeng Wang, Benjamin Danek, Jimeng Sun
Validating scientific hypotheses is a central challenge in biomedical research, and remains difficult for artificial intelligence (AI) agents due to the complexity of real-world da…
Developing Large Language Models for Clinical Research Using One Million Clinical Trials
Zifeng Wang, Jiacheng Lin, Qiao Jin +5
Developing artificial intelligence (AI) for clinical research requires a comprehensive data foundation that supports model training and rigorous evaluation. Here, we introduce Tria…
s3: You Don't Need That Much Data to Train a Search Agent via RL
Pengcheng Jiang, Xueqiang Xu, Jiacheng Lin +4
Retrieval-augmented generation (RAG) systems empower large language models (LLMs) to access external knowledge during inference. Recent advances have enabled LLMs to act as search…
DeepRetrieval: Hacking Real Search Engines and Retrievers with Large Language Models via Reinforcement Learning
Pengcheng Jiang, Jiacheng Lin, Lang Cao +5
Information retrieval systems are crucial for enabling effective access to large document collections. Recent approaches have leveraged Large Language Models (LLMs) to enhance retr…
InformGen: An AI Copilot for Accurate and Compliant Clinical Research Consent Document Generation
Zifeng Wang, Junyi Gao, Benjamin Danek +5
Leveraging large language models (LLMs) to generate high-stakes documents, such as informed consent forms (ICFs), remains a significant challenge due to the extreme need for regula…
A foundation model for human-AI collaboration in medical literature mining
Zifeng Wang, Lang Cao, Qiao Jin +20
Systematic literature review is essential for evidence-based medicine, requiring comprehensive analysis of clinical trial publications. However, the application of artificial intel…
A Perspective for Adapting Generalist AI to Specialized Medical AI Applications and Their Challenges
Zifeng Wang, Hanyin Wang, Benjamin Danek +6
The integration of Large Language Models (LLMs) into medical applications has sparked widespread interest across the healthcare industry, from drug discovery and development to cli…
SynRL: Aligning Synthetic Clinical Trial Data with Human-preferred Clinical Endpoints Using Reinforcement Learning
Trisha Das, Zifeng Wang, Afrah Shafquat +4
Each year, hundreds of clinical trials are conducted to evaluate new medical interventions, but sharing patient records from these trials with other institutions can be challenging…
Can Large Language Models Replace Data Scientists in Biomedical Research?
Zifeng Wang, Benjamin Danek, Ziwei Yang +2
Data science plays a critical role in biomedical research, but it requires professionals with expertise in coding and medical data analysis. Large language models (LLMs) have shown…
Entry-level guide to the use of large language models for medical research
Qiao Jin, Nicholas Wan, Robert Leaman +20
Frontier large language models (LLMs), such as GPT-5, Claude 4.5, Gemini 3, Llama 4, and DeepSeek-R1, represent a transformative class of AI tools capable of revolutionizing variou…
Panacea: A foundation model for clinical trial search, summarization, design, and recruitment
Jiacheng Lin, Hanwen Xu, Zifeng Wang +2
Clinical trials are fundamental in developing new drugs, medical devices, and treatments. However, they are often time-consuming and have low success rates. Although there have bee…
Accelerating Clinical Evidence Synthesis with Large Language Models
Zifeng Wang, Lang Cao, Benjamin Danek +3
Synthesizing clinical evidence largely relies on systematic reviews of clinical trials and retrospective analyses from medical literature. However, the rapid expansion of publicati…
TriSum: Learning Summarization Ability from Large Language Models with Structured Rationale
Pengcheng Jiang, Cao Xiao, Zifeng Wang +3
The advent of large language models (LLMs) has significantly advanced natural language processing tasks like text summarization. However, their large size and computational demands…
GenRES: Rethinking Evaluation for Generative Relation Extraction in the Era of Large Language Models
Pengcheng Jiang, Jiacheng Lin, Zifeng Wang +2
The field of relation extraction (RE) is experiencing a notable shift towards generative relation extraction (GRE), leveraging the capabilities of large language models (LLMs). How…
PILOT: Legal Case Outcome Prediction with Case Law
Lang Cao, Zifeng Wang, Cao Xiao +1
Machine learning shows promise in predicting the outcome of legal cases, but most research has concentrated on civil law cases rather than case law systems. We identified two uniqu…
CITING: Large Language Models Create Curriculum for Instruction Tuning
Tao Feng, Zifeng Wang, Jimeng Sun
The recent advancement of large language models (LLMs) has been achieved through a combo of instruction tuning and human alignment. However, building manually crafted instruction d…
UniPredict: Large Language Models are Universal Tabular Classifiers
Ruiyu Wang, Zifeng Wang, Jimeng Sun
Tabular data prediction is a fundamental machine learning task for many applications. Existing methods predominantly employ discriminative modeling and operate under the assumption…
MindMap: Knowledge Graph Prompting Sparks Graph of Thoughts in Large Language Models
Yilin Wen, Zifeng Wang, Jimeng Sun
Large language models (LLMs) have achieved remarkable performance in natural language understanding and generation tasks. However, they often suffer from limitations such as diffic…
Matching Patients to Clinical Trials with Large Language Models
Qiao Jin, Zifeng Wang, Charalampos S. Floudas +7
Patient recruitment is challenging for clinical trials. We introduce TrialGPT, an end-to-end framework for zero-shot patient-to-trial matching with large language models. TrialGPT…
PyTrial: Machine Learning Software and Benchmark for Clinical Trial Applications
Zifeng Wang, Brandon Theodorou, Tianfan Fu +2
Clinical trials are conducted to test the effectiveness and safety of potential drugs in humans for regulatory approval. Machine learning (ML) has recently emerged as a new tool to…
MediTab: Scaling Medical Tabular Data Predictors via Data Consolidation, Enrichment, and Refinement
Zifeng Wang, Chufan Gao, Cao Xiao +1
Tabular data prediction has been employed in medical applications such as patient health risk prediction. However, existing methods usually revolve around the algorithm design whil…