131 citations · 215 across the 5 of their papers we have counts for
5 papers
Mechanics of allostery: contrasting the induced fit and population shift scenarios
Riccardo Ravasio, Solange Flatt, Le Yan +3
In allosteric proteins, binding a ligand can affect function at a distant location, for example by changing the binding affinity of a substrate at the active site. The induced fit…
Maximum-energy records in glassy energy landscapes
Ivailo Hartarsky, Marco Baity-Jesi, Riccardo Ravasio +2
We study the evolution of the maximum energy $E_\max(t)$ reached between time and time in the dynamics of simple models with glassy energy landscapes, in instant quenches f…
Direct Coupling Analysis of Epistasis in Allosteric Materials
Barbara Bravi, Riccardo Ravasio, Carolina Brito +1
In allosteric proteins, the binding of a ligand modifies function at a distant active site. Such allosteric pathways can be used as target for drug design, generating considerable…
Principles for optimal cooperativity in allosteric materials
Le Yan, Riccardo Ravasio, Carolina Brito +1
Allosteric proteins transmit a mechanical signal induced by binding a ligand. However, understanding the nature of the information transmitted and the architectures optimizing such…
Architecture and Co-Evolution of Allosteric Materials
Le Yan, Riccardo Ravasio, Carolina Brito +1
We introduce a numerical scheme to evolve functional materials that can accomplish a specified mechanical task. In this scheme, the number of solutions, their spatial architectures…