3 papers
physics.bio-ph2019
Mechanics of allostery: contrasting the induced fit and population shift scenarios
Riccardo Ravasio, Solange Flatt, Le Yan +3
In allosteric proteins, binding a ligand can affect function at a distant location, for example by changing the binding affinity of a substrate at the active site. The induced fit…
cond-mat.dis-nn2019
Maximum-energy records in glassy energy landscapes
Ivailo Hartarsky, Marco Baity-Jesi, Riccardo Ravasio +2
We study the evolution of the maximum energy $E_\max(t)$ reached between time and time in the dynamics of simple models with glassy energy landscapes, in instant quenches f…
q-bio.QM2018
Direct Coupling Analysis of Epistasis in Allosteric Materials
Barbara Bravi, Riccardo Ravasio, Carolina Brito +1
In allosteric proteins, the binding of a ligand modifies function at a distant active site. Such allosteric pathways can be used as target for drug design, generating considerable…