Zero-order ultrasensitivity: A study of criticality and fluctuations under the total quasi-steady state approximation in the linear noise regime

P. K. Jithinraj, Ushasi Roy, Manoj Gopalakrishnan

Zero-order ultrasensitivity (ZOU) is a long known and interesting phenomenon in enzyme networks. Here, a substrate is reversibly modified by two antagonistic enzymes (a "push-pull"…