156 citations · 405 across the 6 of their papers we have counts for
6 papers
Inference of germinal center evolutionary dynamics via simulation-based deep learning
Duncan K Ralph, Athanasios G Bakis, Jared Galloway +6
B cells and the antibodies they produce are vital to health and survival, motivating research on the details of the mutational and evolutionary processes in the germinal centers (G…
A Bayesian Phylogenetic Hidden Markov Model for B Cell Receptor Sequence Analysis
Amrit Dhar, Duncan K. Ralph, Vladimir N. Minin +1
The human body is able to generate a diverse set of high affinity antibodies, the soluble form of B cell receptors (BCRs), that bind to and neutralize invading pathogens. The natur…
Predicting B Cell Receptor Substitution Profiles Using Public Repertoire Data
Amrit Dhar, Kristian Davidsen, Frederick A. Matsen +1
B cells develop high affinity receptors during the course of affinity maturation, a cyclic process of mutation and selection. At the end of affinity maturation, a number of cells s…
Per-sample immunoglobulin germline inference from B cell receptor deep sequencing data
Duncan K. Ralph, Frederick A. Matsen
The collection of immunoglobulin genes in an individual's germline, which gives rise to B cell receptors via recombination, is known to vary significantly across individuals. In hu…
Likelihood-based inference of B-cell clonal families
Duncan K. Ralph, Frederick A. Matsen
The human immune system depends on a highly diverse collection of antibody-making B cells. B cell receptor sequence diversity is generated by a random recombination process called…
Consistency of VDJ rearrangement and substitution parameters enables accurate B cell receptor sequence annotation
Duncan K. Ralph, Frederick A. Matsen
VDJ rearrangement and somatic hypermutation work together to produce antibody-coding B cell receptor (BCR) sequences for a remarkable diversity of antigens. It is now possible to s…