23 citations · 36 across the 11 of their papers we have counts for
13 papers
Phenotype control and elimination of variables in Boolean networks
Elisa Tonello, Loïc Paulevé
We investigate how elimination of variables can affect the asymptotic dynamics and phenotype control of Boolean networks. In particular, we look at the impact on minimal trap space…
Attractor identification in asynchronous Boolean dynamics with network reduction
Elisa Tonello, Loïc Paulevé
Identification of attractors, that is, stable states and sustained oscillations, is an important step in the analysis of Boolean models and exploration of potential variants. We de…
Reduction for asynchronous Boolean networks: elimination of negatively autoregulated components
Robert Schwieger, Elisa Tonello
To simplify the analysis of Boolean networks, a reduction in the number of components is often considered. A popular reduction method consists in eliminating components that are no…
Attractor separation and signed cycles in asynchronous Boolean networks
Adrien Richard, Elisa Tonello
The structure of the graph defined by the interactions in a Boolean network can determine properties of the asymptotic dynamics. For instance, considering the asynchronous dynamics…
Node and edge control strategy identification via trap spaces in Boolean networks
Laura Cifuentes-Fontanals, Elisa Tonello, Heike Siebert
The study of control mechanisms of biological systems allows for interesting applications in bioengineering and medicine, for instance in cell reprogramming or drug target identifi…
Linear cuts in Boolean networks
Aurélien Naldi, Adrien Richard, Elisa Tonello
Boolean networks are popular tools for the exploration of qualitative dynamical properties of biological systems. Several dynamical interpretations have been proposed based on the…
Control in Boolean networks with model checking
Laura Cifuentes-Fontanals, Elisa Tonello, Heike Siebert
Understanding control mechanisms in biological systems plays a crucial role in important applications, for instance in cell reprogramming. Boolean modeling allows the identificatio…
Control Strategy Identification via Trap Spaces in Boolean Networks
Laura Cifuentes Fontanals, Elisa Tonello, Heike Siebert
The control of biological systems presents interesting applications such as cell reprogramming or drug target identification. A common type of control strategy consists in a set of…
Realizations of kinetic differential equations
G. Craciun, M. D. Johnston, G. Szederkényi +3
The induced kinetic differential equation of a reaction network endowed with mass action type kinetics is a system of polynomial differential equations. The problem studied here is…
Boolean analysis of lateral inhibition
Elisa Tonello, Heike Siebert
We study Boolean networks which are simple spatial models of the highly conserved Delta-Notch system. The models assume the inhibition of Delta in each cell by Notch in the same ce…
Local negative circuits and cyclic attractors in Boolean networks with at most five components
Elisa Tonello, Etienne Farcot, Claudine Chaouiya
We consider the following question on the relationship between the asymptotic behaviours of asynchronous dynamics of Boolean networks and their regulatory structures: does the pres…
Network translation and steady state properties of chemical reaction systems
Elisa Tonello, Matthew D. Johnston
Network translation has recently been used to establish steady state properties of mass action systems by corresponding the given system to a generalized one which is either dynami…
On the conversion of multivalued to Boolean dynamics
Elisa Tonello
Results and tools on discrete interaction networks are often concerned with Boolean variables, whereas considering more than two levels is sometimes useful. Multivalued networks ca…