activity
20182022
most citedStructural insights into characterizing binding sites in EGFR kinase mutants

57 citations · 113 across the 5 of their papers we have counts for

collaborators

7 papers

q-bio.BM2022

Reinforcement Learning for Personalized Drug Discovery and Design for Complex Diseases: A Systems Pharmacology Perspective

Ryan K. Tan, Yang Liu, Lei Xie

Many multi-genic systemic diseases such as neurological disorders, inflammatory diseases, and the majority of cancers do not have effective treatments yet. Reinforcement learning p…

quant-ph20211 cited

Exploiting Different Levels of Parallelism in the Quantum Control Microarchitecture for Superconducting Qubits

Mengyu Zhang, Lei Xie, Zhenxing Zhang +7

As current Noisy Intermediate Scale Quantum (NISQ) devices suffer from decoherence errors, any delay in the instruction execution of quantum control microarchitecture can lead to t…

cs.LG20213 cited

CODE-AE: A Coherent De-confounding Autoencoder for Predicting Patient-Specific Drug Response From Cell Line Transcriptomics

Di He, Lei Xie

Accurate and robust prediction of patient's response to drug treatments is critical for developing precision medicine. However, it is often difficult to obtain a sufficient amount…

cs.LG202052 cited

Molecular Mechanics-Driven Graph Neural Network with Multiplex Graph for Molecular Structures

Shuo Zhang, Yang Liu, Lei Xie

The prediction of physicochemical properties from molecular structures is a crucial task for artificial intelligence aided molecular design. A growing number of Graph Neural Networ…

cs.LG2020

A Cross-Level Information Transmission Network for Predicting Phenotype from New Genotype: Application to Cancer Precision Medicine

Di He, Lei Xie

An unsolved fundamental problem in biology and ecology is to predict observable traits (phenotypes) from a new genetic constitution (genotype) of an organism under environmental pe…

cs.LG2019

Improving Attention Mechanism in Graph Neural Networks via Cardinality Preservation

Shuo Zhang, Lei Xie

Graph Neural Networks (GNNs) are powerful to learn the representation of graph-structured data. Most of the GNNs use the message-passing scheme, where the embedding of a node is it…