Using schematic models to understand the microscopic basis for inverted solubility in $\gamma$D-crystallin

Irem Altan, Jennifer McManus, Patrick Charbonneau

Inverted solubility--a crystal melting upon cooling--is observed in a handful of proteins, such as carbomonoxy hemoglobin and $\gamma$D-crystallin. In human $\gamma$D-crystallin, the phenome…