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q-bio.QM2026
From Syntax to Semantics: Geometric Stability as the Missing Axis of Perturbation Biology
Prashant C. Raju
The capacity to precisely edit genomes has outpaced our ability to predict the consequences. A cell can be genetically perfect and therapeutically useless: edited exactly as intend…
q-bio.QM2026
Directional coherence and effect magnitude in single-cell CRISPR perturbation responses
Prashant C. Raju
Single-cell CRISPR screens summarize each perturbation by how far cells move from their unperturbed state, averaging over cell-to-cell variation. Whether the cells moved together i…