329 citations · 428 across the 6 of their papers we have counts for
7 papers
From quantitative modeling of fluorescence experiments on biomolecules to the prediction of spectroscopic dye properties
Thomas-Otavio Peulen, Daria Maksutova, Thorben Cordes
Fluorescence spectroscopy and modeling provide powerful means to characterize biomacromolecular structures, dynamics, and interactions. Förster resonance energy transfer serves as…
tttrlib: modular software for integrating fluorescence spectroscopy, imaging, and molecular modeling
Thomas-Otavio Peulen, Katherina Hemmen, Annemarie Greife +6
We introduce software for reading, writing and processing fluorescence single-molecule and image spectroscopy data and developing analysis pipelines that unifies various spectrosco…
Unraveling multi-state molecular dynamics in single-molecule FRET experiments -- Part II: Quantitative analysis of multi-state kinetic networks
Oleg Opanasyuk, Anders Barth, Thomas-Otavio Peulen +4
Single-molecule Förster Resonance Energy Transfer (smFRET) is ideally suited to resolve the dynamics of biomolecules. A significant challenge to date is capturing and quantifying t…
Unraveling multi-state molecular dynamics in single-molecule FRET experiments- Part I: Theory of FRET-Lines
Anders Barth, Oleg Opanasyuk, Thomas-Otavio Peulen +4
Conformational dynamics of biomolecules are of fundamental importance for their function. Single-molecule Förster Resonance Energy Transfer (smFRET) is a powerful approach to infor…
The FRET-based structural dynamics challenge -- community contributions to consistent and open science practices
Eitan Lerner, Benjamin Ambrose, Anders Barth +23
Single-molecule Förster resonance energy transfer (smFRET) has become a mainstream technique for probing biomolecular structural dynamics. The rapid and wide adoption of the techni…
Automated and optimally FRET-assisted structural modeling
Mykola Dimura, Thomas O. Peulen, Hugo Sanabria +4
FRET experiments can yield state-specific structural information on complex dynamic biomolecular assemblies. However, FRET experiments need to be combined with computer simulations…
Resolving dynamics and function of transient states in single enzyme molecules
Hugo Sanabria, Dmitro Rodnin, Katherina Hemmen +9
We used a hybrid fluorescence spectroscopic toolkit to monitor T4 Lysozyme (T4L) in action. By unraveling the kinetic and dynamic interplay of the conformational states, we sought…