3 papers
stat.AP2023
Incorporating patient-reported outcomes in dose-finding clinical trials with continuous patient enrollment
Anaïs Andrillon, Lucie Biard, Shing M. Lee
Dose-finding clinical trials in oncology aim to estimate the maximum tolerated dose (MTD), based on safety traditionally obtained from the clinician's perspective. While the collec…
stat.AP2023
Precision Dose-finding Cancer Clinical Trials in the Setting of Broadened Eligibility
Rebecca B. Silva, Bin Cheng, Richard D. Carvajal +1
Broadening eligibility criteria in cancer trials has been advocated to represent the true patient population more accurately. While the advantages are clear in terms of generalizab…
stat.AP2019
A simulation study of methods for handling disease progression in dose-finding clinical trials
Lucie Biard, Bin Cheng, Gulam A. Manji +1
In traditional dose-finding studies, dose-limiting toxicity (DLT) is determined within a fixed time observation window where DLT is often defined as a binary outcome. In the settin…