3 papers
q-bio.BM2026
DegradeQuery: Counterfactual Tuple Pretraining for Context-Aware PROTAC Degradation Prediction
Dong Xu, Zhangfan Yang, Jiantao Wu +3
Proteolysis-targeting chimeras (PROTACs) induce protein degradation by recruiting a target protein to an E3 ubiquitin ligase, making degradation a joint outcome of the degrader mol…
cs.LG2026
Rethinking Drug-Drug Interaction Modeling as Generalizable Relation Learning
Dong Xu, Jiantao Wu, Qihua Pan +3
Drug-drug interaction (DDI) prediction is central to drug discovery and clinical development, particularly in the context of increasingly prevalent polypharmacy. Although existing…
cs.CV2025
Rethinking Positive Pairs in Contrastive Learning
Jiantao Wu, Sara Atito, Zhenhua Feng +3
The training methods in AI do involve semantically distinct pairs of samples. However, their role typically is to enhance the between class separability. The actual notion of simil…