2 papers
physics.bio-ph2021
smFRET reveals DHX36 repetitive binding,not unfolding,of G-quadruplexes
Hai-Lei Guo, Na-Nv Liu, Xu-Guang Xi
Our data challenge Chen et al.'s interpretation of smFRET results, i.e. the repetitive unfolding of G4 with one-base translocations. We believe that the observed oscillatory curve…
q-bio.BM2019
DHX36-mediated G-quadruplex unfolding is ATP-independent?
Hai-Lei Guo, Wei-Fei Chen, Stephane Rety +6
Chen et al. solved the crystal structure of bovine DHX36 bound to a DNA with a G-quadruplex (G4) and a single-stranded DNA segment. They believed that the mechanism they proposed m…