6 papers
Subcompartmentalization of polyampholyte species in organelle-like condensates is promoted by charge pattern mismatch and strong excluded-volume interaction
Tanmoy Pal, Jonas Wessén, Suman Das +1
Polyampholyte field theory and explicit-chain molecular dynamics models of sequence-specific phase separation of a system with two intrinsically disordered protein (IDP) species in…
Comparative Roles of Charge, and Hydrophobic Interactions in Sequence-Dependent Phase Separation of Intrinsically Disordered Proteins
Suman Das, Yi-Hsuan Lin, Robert M. Vernon +2
Endeavoring toward a transferable, predictive coarse-grained explicit-chain model for biomolecular condensates underlain by liquid-liquid phase separation (LLPS), we conducted mult…
Analytical Theory for Sequence-Specific Binary Fuzzy Complexes of Charged Intrinsically Disordered Proteins
Alan N. Amin, Yi-Hsuan Lin, Suman Das +1
Intrinsically disordered proteins (IDPs) are important for biological functions. In contrast to folded proteins, molecular recognition among certain IDPs is "fuzzy" in that their b…
Coarse-Grained Residue-Based Models of Disordered Protein Condensates: Utility and Limitations of Simple Charge Pattern Parameters
Suman Das, Alan Amin, Yi-Hsuan Lin +1
Biomolecular condensates undergirded by phase separations of proteins and nucleic acids serve crucial biological functions. To gain physical insights into their genetic basis, we s…
Cascade of transitions in molecular information theory
Suman G. Das, Madan Rao, Garud Iyengar
Biological organisms are open, adaptve systems that can respond to changes in environment in specific ways. Adaptation and response can be posed as an optimization problem, with a…
A Lattice Model of Charge-Pattern-Dependent Polyampholyte Phase Separation
Suman Das, Adam Eisen, Yi-Hsuan Lin +1
In view of recent intense experimental and theoretical interests in the biophysics of liquid-liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs), heteropolym…