Interstitial flow potentiates TGF-$\beta$/Smad-signaling activity in lung cancer spheroids in a 3D-microfluidic chip

Zaid Rahman, Ankur Deep Bordoloi, Haifa Rouhana +4

Within the tumor microenvironment (TME), cancer cells use mechanotransduction pathways to convert biophysical forces to biochemical signals. However, the underlying mechanisms and…