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Nanoscale Protein Diffusion in Supercooled Cryoprotectant Solutions
Maddalena Bin, Anita Girelli, Mariia Filianina +15
Vitrification during cryopreservation requires a quantitative understanding of protein transport in deeply supercooled cryoprotectant solutions, yet direct measurements at molecula…
Coherent X-rays reveal anomalous molecular diffusion and cage effects in crowded protein solutions
Anita Girelli, Maddalena Bin, Mariia Filianina +38
Understanding protein motion within the cell is crucial for predicting reaction rates and macromolecular transport in the cytoplasm. A key question is how crowded environments affe…
X-ray photon correlation spectroscopy of hydrated lysozyme at elevated pressures
Milla à hlfeldt, Maddalena Bin, Anita Girelli +12
Pressure provides a powerful parameter to control the protein conformation state, which at sufficiently high values can lead to unfolding. Here, we investigate the effects of incre…
Depletion-Induced Interactions Modulate Nanoscale Protein Diffusion in Polymeric Crowder Solutions
Michelle Dargasz, Nimmi Das Anthuparambil, Sebastian Retzbach +26
Macromolecular crowding plays a crucial role in modulating protein dynamics in cellular and in vitro environments. Polymeric crowders such as dextran and Ficoll are known to induce…
Softness and Hydrodynamic Interactions Regulate Lipoprotein Transport in Crowded Yolk Environments
Nimmi Das Anthuparambil, Michelle Dargasz, Sonja Timmermann +27
Low-density lipoproteins (LDLs) serve as nutrient reservoirs in egg yolk for embryonic development and as promising drug carriers. Both roles critically depend on their mobility in…
3D evolution of protein networks and lipid globules in heat-treated egg yolk
Felix Wittwer, Nimmi Das Anthuparambil, Frederik Unger +5
Upon heating, egg yolk transforms from a liquid to a gel due to protein denaturation. This process can serve as a useful model to better understand protein denaturation in general.…